GRUPO DE GENÉTICA MOLECULAR HUMANA Y ANIMAL RNM-924 (Animal and Human Molecular Genetics Group) Departamento de Biología Experimental |
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Primary microcephaly (MCPH) is a rare congenital disorder characterized by a pronounced reduction of brain size and mental retardation. Mutations in MCPH1, one of the genes involved in this syndrome, alter the processes of chromosome condensation and biorientation during mitosis in all cell types. Recent data highlight the importance of MCPH1 also for the functionality of G2/M cell cycle checkpoints. Our research aims to investigate the contribution of MCPH1 and related factors for coupling chromosome division and cell cycle progression. These investigations will add new insights about the importance of this crosstalk in the context of human neurogenesis.
Principal Investigator:
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Pagina mantenida por Pedro Lorite Martínez Universidad de Jaén Departamento de Biología Experimental Área de Genética Tfn: +34 953 212769
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