(Animal and Human Molecular Genetics Group)

Departamento de Biología Experimental




Cell, molecular and immunological research in celiac disease



Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be drive by exogenous antigen and how can be reasonably consider as a model of organ-specific autoimmunity.


Principal Investigator:



María Isabel Torres López


Despacho: Edificio B3-361

Teléfono: +34-953-212762


Researcher ID: G-8789-2015




Teresa Palomeque Messía

Pedro Lorite Martínez

Candelaria Ponce de León Collado


Research interest:


(1) In vitro evaluation the immunotoxic ability of the peptidic fragments derived from gluten. The celiac immunotoxic potential of alfa-gliadins
(2) The role of tolerance molecules and immune checkpoints in celiac disease





Dysregulation of the PD-1/PD-L1 pathway contributes to the pathogenesis of celiac disease.

Ponce de León C, Angel López-Casado M, Lorite P, Palomeque T, Torres MI

Cell Mol Immunol. 2019 Sep;16(9):777-779. doi: 10.1038/s41423-019-0256-


Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species.

Ruiz-Carnicer Á, Comino I, Segura V, Ozuna CV, Moreno ML, López-Casado MÁ, Torres MI, Barro F, Sousa C.

Nutrients. 2019 Jan 22;11(2). pii: E220. doi: 10.3390/nu11020220


Celiac Disease Autoimmunity.

López Casado MÁ, Lorite P, Ponce de León C, Palomeque T, Torres MI.

Arch Immunol Ther Exp (Warsz). 2018 Dec;66(6):423-430. doi: 10.1007/s00005-018-0520-z


Selective capture of most celiac immunogenic peptides from hydrolyzed gluten proteins.

Moreno Mde L, Muñoz-Suano A, López-Casado MÁ, Torres MI, Sousa C, Cebolla Á.

Food Chem. 2016 Aug 15;205:36-42. doi: 10.1016/j.foodchem.2016.02.066


Potential role of the IL-33/ST2 axis in celiac disease.

López-Casado MA, Lorite P, Palomeque T, Torres MI.

Cell Mol Immunol. 2017 Mar;14(3):285-292. doi: 10.1038/cmi.2015.85


Identification and in vitro reactivity of celiac immunoactive peptides in an apparent gluten-free beer.

Real A, Comino I, Moreno Mde L, López-Casado MÁ, Lorite P, Torres MI, Cebolla Á, Sousa C.

PLoS One. 2014 Jun 25;9(6):e100917. doi: 10.1371/journal.pone.0100917


Molecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac disease.

Real A, Comino I, de Lorenzo L, Merchán F, Gil-Humanes J, Giménez MJ, López-Casado MÁ, Torres MI, Cebolla Á, Sousa C, Barro F, Pistón F.

PLoS One. 2012;7(12):e48365. doi: 10.1371/journal.pone.0048365.


Significant differences in coeliac immunotoxicity of barley varieties.

Comino I, Real A, Gil-Humanes J, Pistón F, de Lorenzo L, Moreno Mde L, López-Casado MÁ, Lorite P, Cebolla A, Torres MI, Barro F, Sousa C.

Mol Nutr Food Res. 2012 Nov;56(11):1697-707. doi: 10.1002/mnfr.201200358


The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation.

Calleja MA, Vieites JM, Montero-Meléndez T, Torres MI, Faus MJ, Gil A, Suárez A.

Br J Nutr. 2013 Feb 14;109(3):394-401. doi: 10.1017/S0007114512001298.


Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease.

Comino I, Real A, de Lorenzo L, Cornell H, López-Casado MÁ, Barro F, Lorite P, Torres MI, Cebolla A, Sousa C.

Gut. 2011 Jul;60(7):915-22. doi: 10.1136/gut.2010.225268


Torres MI, Lopez Casado M A, Comino I, Cebolla A, Ríos A, Sousa C. ¿Presentan intolerancia alimenticia a la avena los pacientes celíacos?. Revista Española de Pediatría Clínica e Investigación 2010;66:203-7


Gonzalez A,  Alegre E, Torres MI, Díaz-Lagares A, Lorite P, Palomeque T, Arroyo A. Evaluation of HLA-G5 plasmatic levels during pregnancy and relationship with the 14-bp polymorphism. American journal of reproductive immunology 2010: 64:367-74.


Torres MI, Luque J, Lorite P, Isla –Tejera B, Palomeque T, Aumente MD, Arizon JM, Peña J. 14-bp polymorphism of HLA-G as genetic determinant in heart transplantation and cyclosporine therapy monitorization. Human Immunology 2009;70:830-5.


Vieites JM, Ramirez-Tortosa MC, Ramirez M, Torres MI, Sánchez-Pozo A, Gil A, Suarez A. Exogenous nucleosides accelerate differentiation of rat intestinal epithelial cells. British Journal of Nutrition 2008; 99(4):732-8.


Torres MI, Ríos A. Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. World Journal of Gastroenterology 2008;14:1972-80.


Nieto N, Mesa MD, Lopez-Pedrosa JM, Torres MI, Rios A, Suarez MD, Suarez A, Gil A.  Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutrition. Digestive Diseases and Sciences 2007; 52(6):1485-96.


Torres MI, Lopez-Casado MA, Lorite Pedro, Ríos A. Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease. Clinical and Experimental Immunology 2007; 148(3): 419-29.


Torres MI, Lorite P, Lopez-Casado MA, Ríos A. A new approach using tissue alkaline phosphatase histochemistry to identify crohn's disease. Pathology research and practice 2007; 203(6):485-89.


Torres MI, Lopez-Casado MA,  Rios.  A new aspects in celiac disease. World Journal of Gastroenterology 2007; 13(8):1156-61.


Luque J, Torres MI,  ,  Aumente MD, Lozano JM, De La Peña J, Garcia-Jurado G,  Gónzalez R,  Alvarez  R,  Arizon JM, Peña J. SHLA-G levels in the monitoring of immunosuppressive therapy and rejection following heart transplantation. Transplant Immunology 2006; 17(1):70-3.


Galisteo M, Suarez A, Montilla MP, Torres MI, Fernández MI, Gil A, Navarro C. Protective effects of rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats. Phytomedicine 2006; 13(1):101-08.


Torres MI, Lopez-Casado MA, Luque J, Peña  J,  Ríos A. New advances in coeliac disease: serum and intestinal expression of HLA-G. International Immunology. 2006; 18(5):713-18.


Luque J, Torres MI, Aumente MD, Marín, J, Garcia G, Gonzalez R, Pascual D, Guerra N, López-Rubio F,  Alvarez R,  Arizon J, Peña J. Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy. Human Immunology. 2006; 67(4):257-63.


Torres MI,  Lopez-Casado MA, Luque J, Peña J,  Ríos A. A soluble HLA-G expression in celiac disease. Tissue Antigens. 2006; 68(4): 335-53.


Sedmera D, Reckova M, Rosengarten C, Torres MI, Gourdie RG, Thompson RP. Optical mapping of electrical activation in the developing heart. Microscopy and Microanalysis. 2005; 11(3):209-15.


Fernandez I,  Fontana L, Gil A, Ríos A, Torres MI.  Dietary supplementation with monounsaturated and long-chain polyunsaturated fatty acids influences the liver structural recovery and hepatocyte binuclearity in female wistar rats in experimental cirrhosis induced by thioacetamide. Experimental and Toxicologic Pathology. 2005; 57(1):65-75.


Perez MJ, Sanchez De Medina F, Torres MI, Gil A, Suarez A. Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. The Journal of Nutrition. 2004; 134(10):2504-08.


Saez-Lara, MJ, Manzano C, Angulo AJ, Suarez A, Torres MI, Gil A, Gómez-Llorente C, Fontana L. Exogenous nucleosides stimulate proliferation of fetal rat hepatocytes. The Journal of Nutrition. 2004; 134(6):1309-16.


Torres MI, Le Discorde M, Lorite P, Ríos A, Gassul MA, Gil A, Maldonado J, Dausset J, Carosella E.  Expression of HLA-G in inflammatory bowel disease provides a potential way to distinguish between ulcerative colitis and crohn's disease. International Immunology. 2004;16(4):579-83.


Torres MI, Le Discorde M, Lorite P, Ríos  A, Gassull MA, Dausset J, Carosella E. Differential expression of HLA-G in inflammatory bowel síndrome. Tissue Antigens. 2003; 62(4):351-5.


Arnaud A, Lopez-Pedrosa, Torres MI, Gil Angel.  Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea. Journal of Pediatric Gastroenterology and Nutrition. 2003;37(2):124-31.


Nieto N, Torres MI, Ríos  A, Gil A. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. The Journal of Nutrition. 2002; 132(1):11-19.


Saez-Lara MJ, Fontana L,  Torres MI, Manzano M, Gil  A. Exogenous nucleosides promote growth and maturation of rat fetal hepatocytes. Hepatology. 2001;34(4):1306-9.


Torres MI, Moreau P, Rouas-Freiss N, Dausset J, Carosella E. HLA-G TODAY. Inmunologia. 2001;20(1):1-18.


Torres MI, Lopez-Gutierrez M, Lopez-Casado MA, Redondo Emilio, Gil A,  Carosella E. Expresión de HLA-G en la enfermedad celíaca. Anales Españoles de Pediatría. 2001;54:63-7.


Nieto N, Torres MI, Fernández MI,  Giron MD, Ríos A, Suarez MD, Gil A. Experimental ulcerative colitis impairs antioxidant defense system in rat intestine. Digestive Diseases and Sciences. 2000; 45(9):1820-7.


Nieto N, Andrade R, Lopez-Pedrosa JM, Lucena MI, Mesa MD, Aguilar J,  Lazo MD, Torres MI, Fernandez MI, Ríos A, Suarez MD, Gil A. Chronic liver injury related to use of bentazepam - an unusual instance of benzodiazepine hepatotoxicity. Digestive Diseases and Sciences. 2000;45(7):1400-4.


Nieto N, Lopez-Pedrosa JM, Mesa MD, Torres MI, Fernández MI, Ríos A, Suarez MD, Gil A. Chronic diarrhea impairs intestinal antioxidant defense system in rats at weaning.

Digestive Diseases and Sciences. 2000;45(10):2044-50.


Peinado MA, Torres MI, Thompsom RP, Esteban-Ruiz, FJ. Immunolocalization of the hnk-1 epitope in the autonomic innervation to the liver and upper digestive tract of the developing rat embryo. Histochemical Journal. 2000;32(7):439-46.


Garrido MD, Torres MI,  Gálvez  JJ,  Zarzuelo  A. Intestinal anti-inflammatory activity of UR-12746, a novel 5- ASA conjugate, on acute and chronic experimental colitis in the rat. British Journal of Pharmacology. 2000;130(8):1949-59.


Lopez-Pedrosa JM, Ramirez M, Torres MI, Gil A. Dietary phospholipids rich in long-chain polyunsaturated fatty acids improve the repair of small intestine in previously malnourished piglets. The Journal of Nutrition. 1999; 129(6): 1149-55.


Fontana L, Moreira E, Torres MI, Periago JL, Sanchez De Medina F,  Gil A. Effects of dietary polyunsaturated fatty acids and nucleotides on tissue fatty acid profiles of rats with carbon tetrachloride-induced liver damage. Clinical Nutrition. 1999; 18(2):93-01.


Garrido MD, Torres MI, Merlos M, Uriach J Zarzuelo A. Oral administration of UR-12746 can ameliorate IBD in rats. Gastroenterology. 1999; 116:3131-5


Peinado MA, Quesada A, Pedrosa JA, Torres MI, Martinez M, Esteban F, Moral ML, Hernández R, Rodrigo J, Peinado JM. Quantitative and ultrastructural changes in glia and pericytes in the parietal cortex of the aging rat. Microscopy Research and Technique. 1998; 43(1):34-42.


Ortega MA, Nuñez MC, Torres MI, Gil Angel, Sánchez-Pozo A. Efecto de los nucleótidos de la dieta sobre la funcionalidad intestinal tras un periodo de ayuno. Nutrición Hospitalaria. 1998; 6-10.


Lopez-Pedrosa JM, Torres MI, Fernández MI, Ríos A, Gil A. Severe malnutrition alters lipid composition and fatty acid profile of small intestine in newborn piglets. The Journal of Nutrition. 1998; 128(2):224-33.


Torres MI, Fernández MI, Gil A, Ríos A. Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide. Life Sciences. 1998; 62(1):13-22.


Ocete MA, Crespo M, Cruz T, González M, Torres MI,  Zarzuelo A, Gálvez JJ, Crespo E, González M. Effects of morin on an experimental model of acute colitis in rats. Pharmacology. 1998;57(5):261-70.


Nieto N, Fernandez MI, Torres MI, Ríos A, Gil A, Suarez MD. Dietary monounsaturated n-3 and n-6 long-chain polyunsaturated fatty acids affect cellular antioxidant defense system in rats with experimental ulcerative colitis induced by trinitrobenzene sulfonic acid. Diseases and Sciences. 1998;43(12):2676-87.


Moreira E, Fontana L, Torres MI, Fernández MI, Ríos A, Sanchez De Medina F, Gil A. Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide. Journal of Hepatology. 1998; 28(4):662-9.


Fernández MI, Torres MI, Gil A, Ríos A. Steatosis and collagen content in experimental liver cirrhosis are affected by dietary monounsaturated and polyunsaturated fatty acids. Scandinavian Journal of Gastroenterology. 1997;32(4):350-6.


Esteban FJ,  Sánchez AM, Torres MI,  Avila R. Distribution of the lipids stored in hepatocytes in the liver of rats fed on olive or sunflower oil diets. Acta Microscopica. 1997;446-9.


Gil-Villarino  A, Torres MI, Zafra MF, García-Peregrin, E. Supplementation of coconut oil from different sources to the diet induces cellular damage and rapid changes in fatty acid composition of chick liver and hepatic mitochondria. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology.1997; 117(3):243-50.


Del Moral ML,  Esteban FJ, Torres MI, Camacho M, Hernández R, Jimenez A, Aránega AE, Pedrosa JA, Peinado MA. High-fat sunflower and olive oil diets affect serum lipid levels in steatotic rat liver differently. Journal of Nutritional Science and Vitaminology. 1997;43(1):155-60.


Ortega MA, Torres MI, Fernández MI, Ríos A, Sánchez-Pozo A, Gil A. Hepatotoxic agent thioacetamide induces biochemical and histological alterations in rat small intestine. Digestive Diseases and Sciences. 1997; 42(8):1715-23.


Torres MI, Fernández MI,  Ríos A, Gil  A. Effect of dietary nucleotides on degree of fibrosis and steatosis induced by oral intake of thioacetamide. Digestive Diseases and Sciences. 1997; 4(6):1322-8.


Fernandez I, Torres MI, Ríos A, Moreira E, Fontana L, Gil  A,; Sanchez De Medina F. Influence of administration of long-chain polyunsaturated fatty acids on process of histological recovery in liver cirrhosis produced by oral intake of thioacetamide. Digestive Diseases and Sciences. 1996;41(1):197-07.


Torres MI, Fernandez I, Fontana L, Gil  A, Sanchez De Medina F, Ríos A. Influence of dietary nucleotides on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide. Gut. 1996; 38(2):260-4.


Torres MI, Ríos A,  Zarzuelo A, Jimenez I Gamez-Montalvo MJ, Utrilla P; Fernandez I,  Osuna I. Effects of luteolin 5-O-beta-rutinoside in streptozotocin-induced diabetic rats. Life Sciences. 1996; 58:2311-6.


Fontana L, Moreira E, Torres MI, Fernandez MI, Ríos A, Sanchez De Medina F, Gil A. Serum amino acid changes in rats with thioacetamide-induced liver cirrhosis. Toxicology. 1996;106:197-06.


Moreira E, Fontana L, Torres-López MI,  Fernandez I, Ríos A, Sanchez De Medina F, Gil A.  Dietary long-chain polyunsaturated fatty-acids influence the recovery of thioacetamide-induced liver-cirrhosis in rats. Journal of Pediatric Gastroenterology and Nutrition 1995; 19(6):461-9.


Gálvez JJ, Sanchez De Medina F, Jimenez J, Torres MI, Fernandez MI, Nuñez MC, Ríos A, Gil A, Zarzuelo A. Effect of quercitrin on lactose-induced chronic diarrhea in rats. Planta Medica. 1995;61(4):302-06.


Bueno JD, Torres MI, Almendros A, Carmona R, Nuñez MC, Rios A,  Gil A. Effect of dietary nucleotides on small-intestinal repair after diarrhea - histological and ultrastructural-changes. Gut. 1994; 35(7):926-33.




 Book chapters 


Torres López MI, López-Casado MA, Ponce de León C, Lorite P, Palomeque.T. Physiology and Pathology of Immune Dysregulation: Regulatory T Cells and Anergy 2017. INTECH. ISBN: 978--953-51-4


Torres López MI, Palomeque Messia T, Lorite Martínez P. New Aspect of Crohn's disease pathogenesis: dysbiotic gut microbiome 2016; 1-14. SM Groups. ISBN: 978-1-944685-90-4


Torres López, MI, Palomeque Messia T, Lorite Martínez P. Celiac Disease and Other Autoimmune Disorders. 2015; 131-51. INTECH. ISBN: 978-953-51-4188


Torres López MI, Palomeque Messia T, Lorite Martínez P. HLA in gastrointestinal inflammatory disorders. Human Leukocyte Antigen 2014; 223-45. INTECH.  ISBN: 978-953-51-1230-3 980-953-307-1107-5.




In the media:


Andalucía Innova 2011

El Mundo 17-07-2011

elPeriodico 16-11-2012

El Mundo 29-12-2013

esandalucia (Europa Press) 09-11-2015

Servicio de Información y Noticias Científicas (SINC) 10-11-2015























Pagina mantenida por

Pedro Lorite Martínez

Universidad de Jaén

Departamento de Biología Experimental

Área de Genética

Tfn: +34 953 212769